Pipeline — registered trials by phase
Infusion Duration Study To Assess Tolerability of Pegloticase Administered With a Shorter Infusion Duration in Subjects With Uncontrolled Gout Receiving Methotrexate
— · Chronic Uncontrolled Gout, Gout, Uncontrolled Gout · Completed · est. 2024-01-18
Rheumatoid Arthritis DMARD Intervention and UtilizationStudy
— · Rheumatoid Arthritis · Completed · est. 2008-06
A Study to Assess Symptom Burden in Subjects With Nonmyeloid Malignancies Receiving Chemotherapy and Aranesp®
— · Anemia · Completed
Long-term, Open-label, Safety Study of Inebilizumab in Neuromyelitis Optica Spectrum Disorder (NMOSD)
— · Neuromyelitis Optica Spectrum Disorder · Active Not Recruiting · est. 2028-06-26
Registry of Etanercept (Enbrel®) In Children With Juvenile Rheumatoid Arthritis
— · Juvenile Rheumatoid Arthritis · Completed · est. 2008-01
Study of Pegloticase in Participants With Uncontrolled Gout Who Have Had a Kidney Transplant
— · Uncontrolled Gout, Kidney Transplant · Completed · est. 2021-07-06
A Study Evaluating TEPEZZA® Treatment in Patients With Chronic (Inactive) Thyroid Eye Disease
— · Thyroid Eye Disease, Chronic (Inactive) Thyroid Eye Disease · Completed · est. 2023-03-17
Observational Safety Study of Etanercept (Enbrel) for Treatment of Psoriasis
— · Psoriasis · Completed · est. 2012-12-11
Organization of Teratology Information Services (OTIS) Autoimmune Diseases in Pregnancy Project
— · Pregnancy · Completed · est. 2014-06
An Open-Label Study to Assess the Rate of Failure of an Enbrel® (Etanercept) SureClick™ Auto-injector in Subjects With Rheumatoid Arthritis
— · Rheumatoid Arthritis · Completed · est. 2006-03
Post Transplant Study
— · Kidney Tansplant, Secondary Hyperparathyroidism, Hyperparathyroidism · Completed
Postmarketing Prospective Study of Melanoma Patients Treated With IMLYGIC® to Characterize Risk of Herpetic Infection
— · Melanoma, Herpetic Infection · Completed · est. 2026-01-30
Canadian Assessment of Patient Outcomes and Effectiveness of Etanercept (Enbrel) in Psoriasis
— · Psoriasis · Completed · est. 2009-07
A Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders
— · Urea Cycle Disorder · Completed · est. 2016-10-17
Characteristics and Management of Postmenopausal Women With Osteoporosis Treated With Prolia® in France
— · Post Menopausal Osteoporosis · Completed · est. 2017-10-26
Bioequivalence Study of Denosumab CP4 Drug Product and Commercially Available Denosumab CP2 Drug Product
— · Healthy Volunteer · Completed · est. 2014-08
Pharmacokinetics and Excretion of [¹⁴C]Etelcalcetide (AMG 416) in Patients With End Stage Renal Disease (ESRD) Receiving Dialysis
— · Secondary Hyperparathyroidism in Patients With ESRD on Hemodialysis · Completed · est. 2014-04-15
Safety, Tolerability, and Pharcodynamics of AMG 853 in Adolescents With Asthma
— · Asthma · Completed · est. 2011-01
Phase 1b Study Evaluating OPomD in Relapsed or Refractory Multiple Myeloma
— · Relapsed or Refractory Multiple Myeloma · Completed · est. 2022-10-06
Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
— · Thoracic Tumors, Non-small Cell Lung Cancer · Active Not Recruiting · est. 2026-10-31
A Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Teprotumumab (AMG 632) Administered Intravenously in Healthy Chinese Participants
— · Healthy Volunteers · Completed · est. 2025-11-22
Study to Evaluate Romosozumab in Children and Adolescents With Osteogenesis Imperfecta
— · Osteogenesis Imperfecta · Completed · est. 2023-03-30
A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)
— · Extensive Stage Small Cell Lung Cancer · Recruiting · est. 2028-03-18
A Study Evaluating Anvumetostat in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)
— · Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers · Active Not Recruiting · est. 2026-10-31
Study to Evaluate the Concentration of Denosumab in Seminal Fluid in Healthy Men After a Single Subcutaneous Dose
— · Healthy Volunteer · Completed · est. 2013-09
A Phase 1, Open-Label Study of Teprotumumab in Patients With Diabetic Macular Edema (DME)
— · Diabetic Macular Edema · Completed · est. 2016-08
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.
— · Ulcerative Colitis, Crohn's Disease · Completed · est. 2014-04
A Single-dose Study in Paediatric Patients Aged 2 to Less Than 18 Years With Secondary Hyperparathyroidism (sHPT) Receiving Haemodialysis
— · Chronic Kidney Disease, Secondary Hyperparathyroidism · Completed · est. 2018-10-31
A Study to Evaluate the Impact of Acid-reducing Agents on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants
— · Healthy Participants · Completed · est. 2020-09-13
Single and Multiple Ascending Dose Study to Evaluate AMG 786 in Healthy Participants and Participants With Obesity
— · Obesity · Completed · est. 2023-08-21
Effect of Coadministration of Sotorasib on the Pharmacokinetics of Rosuvastatin in Healthy Participants
— · Healthy Participants · Completed · est. 2021-10-10
A Phase 1 Study in Subjects With Relapsed or Refractory Multiple Myeloma
— · Multiple Myeloma · Completed · est. 2018-11-30
Estimation Study to Assess the Effect of Severe Renal Impairment and End-stage Renal Disease Hemodialysis on the Pharmacokinetics of Evolocumab
— · Hyperlipidemia, Mixed Dyslipidemia · Completed · est. 2014-12-19
Evaluation of Xaluritamig in High-Risk, Biochemically Recurrent, Non-metastatic Castrate-sensitive Prostate Cancer
— · Prostate Cancer, High-risk Biochemical Recurrence, High Risk Biochemical Recurrence of Non-metastatic Castration-sensitive Prostate Cancer · Active Not Recruiting · est. 2027-03-13
A Study of Single and Multiple Ascending Doses of VIB1116 in Rheumatic Diseases
— · Dendritic Cell -Mediated Rheumatic Diseases · Completed · est. 2023-07-03
A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation
— · Advanced Solid Tumors · Recruiting · est. 2028-07-01
NOLAN: Naproxen or Loratadine and Neulasta
— · Bone Pain in Stage I - III Breast Cancer · Completed · est. 2015-03-18
Pegfilgrastim as Support to Pediatric Sarcoma Patients Receiving Chemotherapy
— · Sarcoma, Neutropenia · Completed · est. 2007-01
Study of Romosozumab (AMG 785) in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing
— · Fracture Healing · Completed · est. 2012-03-06
AMG 151 Amgen Protocol Number 20100761
— · Diabetes Mellitus · Completed · est. 2012-10
Phase 2 Study of Carfilzomib in Relapsed and Refractory Multiple Myeloma
— · Multiple Myeloma · Completed · est. 2010-11
Efficacy and Safety Study of Apremilast in Subjects With Moderate to Severe Atopic Dermatitis
— · Dermatitis, Atopic Dermatitis · Completed · est. 2015-10
A Study to Evaluate the Safety and Efficacy of CCX140-B in Subjects With Type 2 Diabetes Mellitus
— · Type 2 Diabetes Mellitus · Completed · est. 2010-10
Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma
— · Melanoma · Completed · est. 2016-08-23
A Study of Subcutaneous Blinatumomab in Children With R/R and and MRD+ B-Cell Precursor Acute Lymphoblastic Leukemia
— · Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia, Minimal Residual Disease + B-Cell Acute Lymphoblastic Leukemia · Active Not Recruiting · est. 2031-03-06
A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL
— · B Cell Precursor Acute Lymphoblastic Leukemia · Active Not Recruiting · est. 2027-11-24
Clinical Trial to Evaluate Safety and Efficacy of CCX168 in ANCA-Associated Vasculitis
— · ANCA-associated Vasculitis · Completed · est. 2016-04-24
Safety, Pharmacokinetics, and Clinical Effects of Cinacalcet (AMG 073) in Primary Hyperparathyroidism
— · Primary Hyperparathyroidism · Completed · est. 1999-12-13
A Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Celiac Disease
— · Celiac Disease · Completed · est. 2017-02-15
Study to Develop a Screening Tool for Functional Capacity in Anemic Subjects With Nonmyeloid Malignancies Receiving Chemotherapy and Darbepoetin Alfa
— · Anemia, Non-Myeloid Malignancies · Completed · est. 2003-06
Fixed Dose NESP Study in Subjects With CRI
— · Pre-Dialysis · Completed · est. 2002-02
AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Prior to Splenectomy
— · Thrombocytopenia, Idiopathic Thrombocytopenic Purpura · Completed · est. 2006-12-01
Etanercept SFP in RA Patients
— · Rheumatoid Arthritis · Completed · est. 2007-08
Study of Darbepoetin Alfa for the Treatment of Anemia of Cancer
— · Anemia, Cancer · Completed · est. 2006-10
Study of Carfilzomib, Daratumumab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple Myeloma.
— · Relapsed Multiple Myeloma, Refractory Multiple Myeloma · Completed · est. 2019-07-14
AMG 162 in the Treatment of Bone Loss in Subjects Undergoing Aromatase Inhibitor Therapy for Non-metastatic Breast Cancer
— · Breast Cancer, Low Bone Mineral Density, Osteopenia · Completed · est. 2007-05-11
Safety and Efficacy of Evolocumab in Combination With Statin Therapy in Adults With Diabetes and Hyperlipidemia or Mixed Dyslipidemia
— · Diabetes, Hyperlipidemia, Mixed Dyslipidemia · Completed · est. 2017-12-06
Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
— · Osteogenesis Imperfecta · Active Not Recruiting · est. 2027-05-04
A Study of Apremilast in Pediatric Participants in Children With Mild to Moderate Plaque Psoriasis
— · Plaque Psoriasis · Completed · est. 2026-08-12
A Study of Darbepoetin Alfa for the Treatment of Anemia in Subjects With Non-Myeloid Malignancy Receiving Multicycle Chemotherapy
— · Anemia, Non-Myeloid Malignancies · Completed · est. 2004-12
Denosumab Adherence Preference Satisfaction Study
— · Osteoporosis · Completed · est. 2009-06-01
An Open-label Study to Evaluate the Effect of Treatment With Romosozumab or Teriparatide in Postmenopausal Women
— · Postmenopausal Osteoporosis · Completed · est. 2015-05-14
Study to Assess Darbepoetin Alfa in Subjects With Chronic Kidney Disease
— · Kidney Disease, Chronic Kidney Disease · Completed · est. 2007-01
MP-376 (Aeroquin™, Levofloxacin for Inhalation) in Patients With Cystic Fibrosis
— · Cystic Fibrosis · Completed · est. 2012-05-07
Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).
— · KRAS p, G12c Mutated /Advanced Metastatic NSCLC · Completed · est. 2022-08-02
Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-3
— · Hyperlipidemia · Completed · est. 2015-11-10
Efficacy Study: Darbepoetin Alfa for the Treatment of Anemia in Patients With Chronic Kidney Disease
— · Anemia, Kidney Disease · Completed · est. 2005-10
Evaluation of Evolocumab (AMG 145) Efficacy in Diabetic Adults With Hypercholesterolemia/Mixed Dyslipidemia
— · Hypercholesterolemia, Mixed Dyslipidemia, Type 2 Diabetes · Completed · est. 2017-08-03
Efficacy and Safety of Etelcalcetide (AMG 416) in the Treatment of Secondary Hyperparathyroidism (SHPT) in Patients With Chronic Kidney Disease on Hemodialysis
— · Hyperparathyroidism, Secondary · Completed · est. 2014-05-22
Darbepoetin Alfa in Patients With Anemic Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
— · MDS · Completed · est. 2015-02-11
A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer
— · Metastatic Castration-resistant Prostate Cancer · Recruiting · est. 2030-01-07
AranespDarbepoetin Alfa
BlincytoBlinatumomab
Epogen/ProcritEpoetin Alfa
NeulastaPegfilgrastim
NeupogenFilgrastim
NplateRomiplostim
ProliaDenosumab
VectibixPanitumumab
XgevaDenosumab
Source: ClinicalTrials.gov (trials where Amgen is lead sponsor; 71 active or completed) and Drugs@FDA (9 approved products). Registry data can include older or partnered programs; the company's own pipeline page is the official list.
SEC filings — insider trading forms excluded
- 10-Q2026-08-05Quarterly report
- 8-K2026-08-04Current report (material event)
- 8-K2026-07-31Current report (material event)
- 11-K2026-06-1111-K
- 11-K2026-06-1111-K
- 8-K2026-05-20Current report (material event)
- 8-K2026-05-19Current report (material event)
- SCHEDULE 13G2026-05-14SCHEDULE 13G
- 10-Q2026-05-01Quarterly report
- 8-K2026-04-30Current report (material event)
- SCHEDULE 13G2026-04-29SCHEDULE 13G
- 8-K2026-04-22Current report (material event)
- DEFA14A2026-04-21DEFA14A
- DEFA14A2026-04-15DEFA14A
- DEFA14A2026-04-07DEFA14A
- DEF 14A2026-04-07Proxy statement
- ARS2026-03-31Annual report to holders
- SCHEDULE 13G/A2026-03-26SCHEDULE 13G/A
- 25-NSE2026-02-2425-NSE
- 8-K2026-02-19Current report (material event)
- 424B22026-02-19424B2
- FWP2026-02-17FWP
- 424B32026-02-17424B3
- S-3ASR2026-02-13S-3ASR
- 10-K2026-02-13Annual report
- 8-K2026-02-03Current report (material event)
- 8-K2026-01-30Current report (material event)
- 10-Q2025-11-05Quarterly report
- 8-K2025-11-04Current report (material event)
- SCHEDULE 13G/A2025-09-08SCHEDULE 13G/A
- 10-Q2025-08-06Quarterly report
- 8-K2025-08-05Current report (material event)
- 11-K2025-06-1211-K
- 11-K2025-06-1211-K
- 8-K2025-05-27Current report (material event)
- 10-Q2025-05-02Quarterly report
- 8-K2025-05-01Current report (material event)
- DEFA14A2025-04-29DEFA14A
- DEFA14A2025-04-17DEFA14A
- SCHEDULE 13G/A2025-04-17SCHEDULE 13G/A
Source: SEC EDGAR. Forms 3/4/5 and 144 (insider transactions) are intentionally left out.