Pipeline — registered trials by phase
A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Within 1 Year After The End of Their Pregnancy
— · Depression, Postpartum · Completed · est. 2026-08-02
Zevalin® Followed by Rituxan® Maintenance in Previously Treated Low Grade Non-Hodgkin's Lymphoma
— · Lymphoma, Non-Hodgkin, Lymphoma, Low-Grade · Completed
Study to Investigate Pregnancy Outcomes in Female Participants Exposed to Subcutaneous (SC) Peginterferon Beta-1a and Intramuscular (IM) Interferon Beta-1a Reported in a German Participant Support Program
— · Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting · Completed · est. 2021-10-15
Tysabri Observational Cohort Study - Multiple Sclerosis (MS) Registries
— · Progressive Multifocal Leukoencephalopathy · Completed · est. 2023-12-31
Ireland Natalizumab (TYSABRI) Observational Program
— · Relapsing-Remitting Multiple Sclerosis · Completed · est. 2017-12-31
A Study Utilising Data From European Union (EU) National Multiple Sclerosis (MS) Registries to Assess the Incidence of Anti-Natalizumab Antibody Among Participants Who Receive Subcutaneous Administration of Natalizumab for Treatment of Relapsing-remitting Multiple Sclerosis (RRMS)
— · Multiple Sclerosis · Active Not Recruiting · est. 2026-10-31
Study of Montelukast on Gastrointestinal Tolerability in Patients With Relapsing Forms of Multiple Sclerosis Receiving Tecfidera
— · Multiple Sclerosis · Completed · est. 2017-02-16
Biomarkers of Anti-TNF-α Therapy Efficacy in Rheumatoid Arthritis to Define Unresponsive Patients
— · Arthritis, Rheumatoid · Completed · est. 2013-07
A Study for Tysabri Participant Preference
— · Relapsing-Remitting Multiple Sclerosis (RRMS) · Completed · est. 2024-04-30
Observational, Postmarketing Surveillance Study of Spinraza Injection (Nusinersen Sodium)
— · Muscular Atrophy, Spinal · Active Not Recruiting · est. 2027-02-05
Effects of Vitamin K on Redness Associated With Injection Site Reactions in Participants Treated With Plegridy
— · Relapsing-Remitting Multiple Sclerosis · Completed · est. 2018-01-27
A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese Participants With SOD-1 Amyotrophic Lateral Sclerosis (ALS)
— · Amyotrophic Lateral Sclerosis · Active Not Recruiting · est. 2027-05-26
Observational Study to Establish Patient-Matched Population Norms for the Multiple Sclerosis Cognition Assessment Battery
— · Healthy · Completed · est. 2015-08
Natural Disease Progression in Participants With Choroideremia
— · Choroideremia · Completed · est. 2021-05-07
Effect of Rituximab on Immunological Recall Response to Specific Antigens in the Treatment of Non-Hodgkin's Lymphoma
— · Non-Hodgkin's Lymphoma · Completed · est. 2007-06
Pediatric Spinal Muscular Atrophy (SMA) China Registry
— · Muscular Atrophy, Spinal · Active Not Recruiting · est. 2027-09-02
Quantitative Magnetic Resonance Imaging (MRI) Sub-Study of MS PATHS
— · Multiple Sclerosis · Completed · est. 2020-04-30
Pregnancy Exposure Registry for Avonex (Interferon Beta-1a)
— · Prenatal Exposure Delayed Effects, Multiple Sclerosis, Pregnancy · Completed · est. 2011-09
A Proof of Concept Study to Evaluate the Effectiveness of Tysabri in Relapsing Remitting Multiple Sclerosis (RRMS) Patient Bladder Function
— · Relapsing-Remitting Multiple Sclerosis · Completed · est. 2011-03
Effectiveness of DMF and Its Impact on PROs in Suboptimal GA Responders With RMS
— · Relapsing Forms of Multiple Sclerosis · Completed · est. 2016-02
Real World Analysis on Lymphocyte Reconstitution After Lymphopenia in Participants Treated by Tecfidera
— · Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting · Completed · est. 2021-06-15
A Study to Explore Association Patterns Between Digital Outcome Assessments From the Konectom™ Platform and Magnetic Resonance Imaging (MRI) Measures of Brain Tissue Damage
— · Multiple Sclerosis (MS) · Completed · est. 2024-04-03
Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of BIIB061 in Healthy Adult Volunteers Including Absolute Bioavailability and Food Effect
— · Healthy · Completed · est. 2014-09
A 24-Hour Pharmacokinetic Determination of BG00012 After Single-Day Oral Administration in Subjects With MS
— · Relapsing Remitting Multiple Sclerosis · Completed · est. 2009-10-31
BIIB033 Single Ascending Dose Study in Healthy Volunteer Subjects
— · Healthy · Completed · est. 2011-10
A Study to Learn More About the Safety of BIIB145 and How it is Processed in the Body of Healthy Adult Participants
— · Healthy Volunteer · Recruiting · est. 2027-02-02
BIIB014 Cardiovascular Monitoring Study
— · Healthy · Completed · est. 2010-04
RTA 408 in the Treatment of Advanced Solid Tumors (NSCLC & Melanoma) - DISCOVER
— · Metastatic or Incurable Non-small Cell Lung Cancer, Relapsed, Refractory Melanoma · Completed · est. 2015-10-01
A Study to Assess the Pharmacodynamic Effects of SAGE-217 in Healthy Adults Using an Insomnia Model
— · Healthy · Completed · est. 2017-12-04
A Study to Find Out How Litifilimab is Processed in the Body in Healthy Participants When Given Under the Skin in 3 Different Ways
— · Healthy Volunteer · Completed · est. 2026-03-10
A Multiple Dose Safety Study of PEG-IFN in Healthy Volunteers
— · Healthy · Completed · est. 2008-05
Effect of Itraconazole on the Pharmacokinetics of Bardoxolone Methyl in Healthy Adults
— · Healthy Volunteers · Completed · est. 2017-11-13
Single-Dose Study of a New Formulation of BIIB061
— · Multiple Sclerosis · Completed · est. 2015-08
A Single-Dose, Pharmacokinetic/Pharmacodynamic (PK/PD), & Safety Study of BIIB017 in Participants With Renal Impairment & Healthy Volunteers
— · Healthy, Renal Insufficiency · Completed · est. 2011-08
Study to Evaluate the Interaction Between a Drug and CNV1014802 in Healthy Subjects
— · Healthy · Completed · est. 2016-08-16
A Study of ALKS 8700, a Monomethyl Fumarate (MMF) Molecule, in Healthy Adults
— · Multiple Sclerosis · Completed · est. 2014-12
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BIIB107 in Healthy Adult Participants
— · Healthy Volunteers · Completed · est. 2024-03-05
Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers
— · Healthy · Completed · est. 2008-04
A Study to Find Out How BIIB141 (Omaveloxolone) is Processed in the Body and to Learn More About Its Safety in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old
— · Friedreich Ataxia · Active Not Recruiting · est. 2030-06-04
A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB133 (Dapirolizumab Pegol) in Healthy Japanese and Caucasian Participants
— · Healthy Volunteers · Completed · est. 2021-04-08
A Study of Mass Balance, Pharmacokinetics, Metabolite Profile, and Metabolite Identification of BIIB122/DNL151 in Healthy Male Subjects
— · Healthy Volunteers · Completed · est. 2021-11-05
Study in Healthy Volunteers to Establish the BioEquivalence of Two Formulations of BG00012
— · Healthy Volunteers · Completed · est. 2011-09
PeptoBismol® Use to Reduce Gastrointestinal Events in Healthy Volunteers Receiving DMF [Tecfidera®] Twice Daily
— · Healthy · Completed · est. 2013-12
A Pharmacokinetic Study of Omaveloxolone in Healthy Volunteers
— · Healthy · Completed · est. 2018-11-20
A Study to Look at How a Single Oral Dose of Carbon-14-Labelled [14C] BIIB091 Moves Through and is Processed by the Body in Healthy Male Participants
— · Healthy Volunteer · Completed · est. 2024-05-11
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis
— · Amyotrophic Lateral Sclerosis · Completed · est. 2021-11-17
Pharmacokinetics Profile Study of BG00012 Standard Formulation and BG00012 Active Pharmaceutical Ingredient
— · Healthy · Completed · est. 2009-10
Crossover Study of CNV1014802 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy
— · Lumbosacral Radiculopathy · Completed · est. 2012-06-30
An Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy
— · Spinal Muscular Atrophy · Completed · est. 2015-01-31
An Open-Label, 18FDG-PET Pharmacodynamic Assessment of the Effect of BIIB021 in Subjects With Gastrointestinal Stromal Tumors (GIST)
— · GIST · Completed · est. 2010-04
A Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy (SMA)
— · Spinal Muscular Atrophy · Completed · est. 2017-08-21
A Study to Evaluate SAGE-217 in Participants With Parkinson's Disease
— · Parkinson Disease · Completed · est. 2017-09-11
Phase IIa Trial to Determine the Effects of Bardoxolone Methyl on Renal Function in Patients With Diabetic Nephropathy
— · Diabetic Nephropathy · Completed · est. 2009-05-31
Hormone Receptor Positive Metastatic Breast Cancer (HR+ mBC) BIIB021 Plus Aromasin Schedule Finding
— · Breast Cancer · Completed · est. 2011-10
Effect of Natalizumab on Infarct Volume in Acute Ischemic Stroke
— · Acute Ischemic Stroke · Completed · est. 2015-02
Safety and Efficacy Extension Study of Daclizumab High Yield Process (DAC HYP) in Participants With Multiple Sclerosis Who Have Completed Study 205MS201 (NCT00390221) to Treat Relapsing-Remitting Multiple Sclerosis
— · Relapsing-Remitting Multiple Sclerosis · Completed · est. 2012-05
Lumiliximab in Combination With FCR in Subjects With Relapsed Chronic Lymphocytic Leukemia (CLL)
— · Chronic Lymphocytic Leukemia · Completed · est. 2010-01
Safety and Efficacy of IDEC-114 in the Treatment of Non-Hodgkin's Lymphoma
— · Non-Hodgkin's Lymphoma · Completed · est. 2002-09
RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR
— · MItochondrial Myopathies · Completed · est. 2017-11-02
Study of the Effect of BG00012 on MRI Lesions and Pharmacokinetics in Pediatric Subjects With RRMS
— · Multiple Sclerosis, Relapsing-Remitting · Completed · est. 2016-09-23
Safety and Efficacy of Natalizumab in Combination With Remicade in the Treatment of Crohn's Disease
— · Crohn's Disease · Completed · est. 2003-07
Exploratory Study of the Safety, Tolerability and Efficacy of Multiple Regimens of Natalizumab in Adult Participants With Relapsing Multiple Sclerosis (MS)
— · Relapsing-Remitting Multiple Sclerosis · Completed · est. 2014-04
A Study to Learn About the Safety of Diroximel Fumarate (DRF) and Dimethyl Fumarate (DMF) and Their Effects on Relapses in Pediatric Participants With Relapsing Forms of Multiple Sclerosis (RMS)
— · Relapsing Forms of Multiple Sclerosis · Not Yet Recruiting · est. 2034-07-28
A Study to Evaluate the Efficacy of SAGE-217 in the Treatment of Adult Participants With Major Depressive Disorder
— · Major Depressive Disorder · Completed · est. 2019-09-24
Characterize Flu-like Symptoms in Relapsing Multiple Sclerosis Patients Transitioning From Non-Pegylated Interferon Beta (IFN-β) Therapies to Peginterferon Beta-1a (BIIB017)
— · Relapsing Multiple Sclerosis · Completed · est. 2015-10
A Study to Evaluate SAGE-217 in Adult Participants With Major Depressive Disorder (MDD)
— · Major Depressive Disorder · Completed · est. 2023-06-22
A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA)
— · Spinal Muscular Atrophy · Completed · est. 2017-02-20
An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 (Tofersen) in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS)
— · Amyotrophic Lateral Sclerosis · Completed · est. 2021-07-16
Long-Term Evaluation of BIIB067 (Tofersen)
— · ALS Caused by Superoxide Dismutase 1 (SOD1) Mutation · Completed · est. 2024-08-12
Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency
— · Renal Insufficiency, Congestive Heart Failure · Completed · est. 2009-10-30
Long-Term Safety and Efficacy Study of Peginterferon Beta-1a
— · Relapsing Multiple Sclerosis · Completed · est. 2015-10
A Study to Learn About the Effect of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Risdiplam (ASCEND)
— · Spinal Muscular Atrophy · Active Not Recruiting · est. 2027-09-24
Effect of BG00012 on Lymphocyte Subsets and Immunoglobulins in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS).
— · Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis · Completed · est. 2017-04-24
A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Primary Membranous Nephropathy (PMN)
— · Primary Membranous Nephropathy · Recruiting · est. 2030-01-28
An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing Remitting Multiple Sclerosis
— · Relapsing-Remitting Multiple Sclerosis · Completed · est. 2016-01
Natalizumab Re-Initiation of Dosing
— · Multiple Sclerosis, Relapsing-Remitting · Completed · est. 2007-12
AvonexInterferon Beta-1A
SpinrazaNusinersen Sodium
TecfideraDimethyl Fumarate
VumerityDiroximel Fumarate
ZinbrytaDaclizumab
ZurzuvaeZuranolone
Source: ClinicalTrials.gov (trials where Biogen is lead sponsor; 76 active or completed) and Drugs@FDA (6 approved products). Registry data can include older or partnered programs; the company's own pipeline page is the official list.
SEC filings — insider trading forms excluded
- SCHEDULE 13G/A2026-08-06SCHEDULE 13G/A
- 10-Q2026-07-29Quarterly report
- 8-K2026-07-29Current report (material event)
- 8-K2026-07-01Current report (material event)
- 8-K2026-06-10Current report (material event)
- 8-K/A2026-06-10Current report (amended)
- SCHEDULE 13G/A2026-06-05SCHEDULE 13G/A
- SCHEDULE 13D/A2026-05-14SCHEDULE 13D/A
- 8-K2026-05-14Current report (material event)
- SC TO-T/A2026-05-14SC TO-T/A
- SC TO-T/A2026-05-12SC TO-T/A
- SC TO-T/A2026-05-06SC TO-T/A
- SCHEDULE 13G/A2026-05-06SCHEDULE 13G/A
- SCHEDULE 13G2026-04-29SCHEDULE 13G
- 10-Q2026-04-29Quarterly report
- 8-K2026-04-29Current report (material event)
- ARS2026-04-28Annual report to holders
- DEFA14A2026-04-28DEFA14A
- DEF 14A2026-04-28Proxy statement
- SC TO-T2026-04-14SC TO-T
- SC TO-C2026-04-07SC TO-C
- SCHEDULE 13D2026-04-06SCHEDULE 13D
- 8-K2026-04-06Current report (material event)
- SC TO-C2026-04-03SC TO-C
- SC TO-C2026-03-31SC TO-C
- 8-K2026-03-31Current report (material event)
- SC TO-C2026-03-31SC TO-C
- SCHEDULE 13G/A2026-03-26SCHEDULE 13G/A
- 8-K2026-03-11Current report (material event)
- 8-K2026-02-11Current report (material event)
- 10-K2026-02-06Annual report
- 8-K2026-02-06Current report (material event)
- SCHEDULE 13G2026-02-05SCHEDULE 13G
- 8-K2026-01-14Current report (material event)
- SCHEDULE 13G/A2025-11-13SCHEDULE 13G/A
- SCHEDULE 13G2025-11-10SCHEDULE 13G
- 10-Q2025-10-30Quarterly report
- 8-K2025-10-30Current report (material event)
- 8-K2025-10-14Current report (material event)
- 8-K2025-07-31Current report (material event)
Source: SEC EDGAR. Forms 3/4/5 and 144 (insider transactions) are intentionally left out.