Pipeline — registered trials by phase
Multicenter Study Using Glaukos® Trabecular Micro-Bypass Stent Model GTS400 Using the G2-M-IS Injector System in Conjunction With Cataract Surgery
— · Primary Open-angle Glaucoma · Completed · est. 2017-08-04
Evaluation of the iStent Versus Two Ocular Hypotensive Agents in Patients With Primary Open-angle Glaucoma (POAG)
— · Eye Diseases, Glaucoma, Open-Angle, Glaucoma · Completed · est. 2012-09
Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus
— · Keratoconus · Recruiting · est. 2027-09
Multicenter Investigation of the Glaukos® Suprachoroidal Stent Model G3 In Conjunction With Cataract Surgery
— · Primary Open-angle Glaucoma · Completed · est. 2019-03-13
Post-approval Study of The Glaukos® iStent® Trabecular Micro-bypass Stent: Extended Follow-up of the Premarket Cohort
— · Primary Open Angle Glaucoma · Completed · est. 2014-04
One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects
— · Primary Open Angle Glaucoma (POAG) · Completed · est. 2019-10-18
Open-Angle Glaucoma Subjects With Cataract Treated With Cataract Surgery Plus One iStent and One iStent Supra
— · Glaucoma, Open-Angle · Completed · est. 2019-12-03
Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents
— · Open-angle Glaucoma · Completed · est. 2019-11-08
Open-angle Glaucoma Subjects on One Ocular Hypotensive Medication Randomized to Treatment With Two Trabecular Micro-bypass Stents or Selective Laser Trabeculoplasty
— · Open-angle Glaucoma · Completed · est. 2019-04-09
Travoprost Intraocular Implant + iStent Infinite
— · Glaucoma, Open-Angle · Recruiting · est. 2027-05
Purpose of This Study is to Evaluate the Safety and Efficacy of One, Two, or Three iStents for the Reduction of Intraocular Pressure in Open-angle Glaucoma Subjects
— · Primary Open Angle Glaucoma (POAG) · Completed · est. 2019-10-08
Observational Trial of the Updated Inserter for the Travoprost Intracameral Implant 75mcg
— · Open Angle Glaucoma (OAG), Ocular Hypertension (OH) · Recruiting · est. 2026-06
Feasibility Study of the Vedera KXS for Treatment of Keratoconus
— · Keratoconus · Completed · est. 2011-03
Glaukos® iStent Infinite Trabecular Micro-Bypass System in Subjects With Mild to Moderate Primary Open-angle Glaucoma
— · Glaucoma · Recruiting · est. 2025-08
A Study of the Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects.
— · Open-Angle Glaucoma · Completed · est. 2008-03
Safety and Efficacy of iDose® TR With Cataract Surgery vs. Cataract Surgery Alone
— · Glaucoma, Open-angle, Ocular Hypertension (OHT), Phacoemulsification Cataract Surgery · Recruiting · est. 2026-08
Open-angle Glaucoma Subjects on One Topical Hypotensive Medication Randomized to Treatment With One or Two Trabecular Micro-bypass Stents in Conjunction With Cataract Surgery
— · Open-angle Glaucoma · Completed · est. 2019-10-18
iDose TR Administration in an Office-Based Surgery Setting
— · Open Angle Glaucoma (OAG), Ocular Hypertension (OHT) · Recruiting · est. 2027-03
Clinical Evaluation of the Vedera KXS for the Treatment of Spherical Myopia
— · Myopia · Completed · est. 2011-08
Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With Two iStents
— · Subjects With Primary Open-angle Glaucoma (POAG) · Completed · est. 2016-07
Prospective Evaluation of Open-Angle Glaucoma Subjects on One Topical Hypotensive Medication Treated With Two iStents
— · Subjects With Primary Open-angle Glaucoma (POAG) · Completed · est. 2016-07
Subjects With Open-angle Glaucoma, Pseudoexfoliative Glaucoma, or Ocular Hypertension Naïve to Medical and Surgical Therapy, Treated With Two Trabecular Micro-bypass Stents (iStent)or Travoprost
— · Open-angle Glaucoma · Completed · est. 2017-01
Two Second-Generation Trabecular Micro-bypass Stents to Treat Glaucoma Subjects on One Hypotensive Medication
— · Open Angle Glaucoma · Completed · est. 2019-11-08
Glaukos® iStent® Trabecular Micro-Bypass Stent System In Conjunction With Cataract Surgery Postmarket Registry
— · Primary Open-angle Glaucoma · Completed · est. 2016-02-16
A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients.
— · Open-Angle Glaucoma · Completed · est. 2013-05
No registered trials in this stage.
Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease
— · Dry Eye Disease, Kerato Conjunctivitis Sicca · Completed · est. 2022-07-27
Evaluation of the Safety and Efficacy of GLK-321 in Subjects With Demodex Blepharitis
— · Demodex Blepharitis · Recruiting · est. 2026-09
A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED
— · Persistent Corneal Epithelial Defect · Recruiting · est. 2025-12
Study of Exchange of Travoprost Intraocular Implant
— · Open Angle Glaucoma · Completed · est. 2022-02-28
Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Presbyopia
— · Presbyopia · Completed · est. 2022-09-06
Study Comparing Travoprost Intraocular Implants to Timolol Ophthalmic Solution
— · Glaucoma Open-angle · Completed · est. 2017-08-01
Performance of the Travoprost Intraocular Implant
— · Glaucoma, Open-Angle, Ocular Hypertension · Completed · est. 2023-11-02
Phase 2 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
— · Glaucoma · Recruiting · est. 2028-03
Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus
— · Keratoconus · Recruiting · est. 2027-04
Clinical Study Comparing Two Models of a Travoprost Intraocular Implant
— · Glaucoma, Open-Angle, Ocular Hypertension · Completed · est. 2022-06-10
Randomized Study Comparing Two Models of a Travoprost Intraocular Implant to Timolol Maleate Ophthalmic Solution, 0.5%
— · Glaucoma, Open-Angle, Ocular Hypertension · Completed · est. 2022-04-05
Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant
— · Glaucoma · Recruiting · est. 2028-06
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
— · Keratoconus · Completed · est. 2015-06
Corneal Collagen Cross-Linking for Ectasia (CXL)
— · Ectasia · Completed · est. 2011-11
Safety and Efficacy of the GTS400 Stent in Conjunction With Cataract
— · Open-angle Glaucoma · Completed · est. 2012-02
GTS400 Stent Implantation in Conjunction With Cataract Surgery in Subjects With Open-angle Glaucoma
— · Glaucoma · Completed · est. 2013-12
Corneal Collagen Cross-linking for Progressive Keratoconus
— · Progressive Keratoconus · Completed · est. 2011-04
A Study of the Trabecular Micro-bypass Stent in Combination With Cataract Surgery in Subjects With Open Angle Glaucoma
— · Open-Angle Glaucoma · Completed · est. 2009-07
Study to Evaluate the Safety and Efficacy of Epi-on Corneal Cross-linking in Eyes With Progressive Keratoconus
— · Progressive Keratoconus · Completed · est. 2019-11-01
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
— · Keratoconus · Completed · est. 2015-07
Epioxa Hd/Epioxa KitRiboflavin 5'-Phosphate Sodium
Idose TrTravoprost
MitosolMitomycin
Photrexa Viscous In Dextran 20%Riboflavin 5'-Phosphate
Photrexa Viscous In Dextran 20%/PhotrexaRiboflavin 5'-Phosphate Sodium
Source: ClinicalTrials.gov (trials where Glaukos is lead sponsor; 50 active or completed) and Drugs@FDA (5 approved products). Registry data can include older or partnered programs; the company's own pipeline page is the official list.
SEC filings — insider trading forms excluded
- 8-K2026-08-03Current report (material event)
- 10-Q2026-07-29Quarterly report
- 8-K2026-07-29Current report (material event)
- 8-K2026-06-03Current report (material event)
- SD2026-05-29SD
- SCHEDULE 13G/A2026-05-15SCHEDULE 13G/A
- 8-K2026-05-04Current report (material event)
- 10-Q2026-04-30Quarterly report
- SCHEDULE 13G2026-04-29SCHEDULE 13G
- 8-K2026-04-29Current report (material event)
- SCHEDULE 13G2026-04-29SCHEDULE 13G
- ARS2026-04-16Annual report to holders
- DEFA14A2026-04-16DEFA14A
- DEF 14A2026-04-16Proxy statement
- SCHEDULE 13G/A2026-03-26SCHEDULE 13G/A
- 8-K2026-03-02Current report (material event)
- S-82026-02-25Employee stock plan
- 10-K2026-02-23Annual report
- 8-K2026-02-17Current report (material event)
- SCHEDULE 13G2026-02-17SCHEDULE 13G
- SCHEDULE 13G2026-02-11SCHEDULE 13G
- SCHEDULE 13G/A2026-02-10SCHEDULE 13G/A
- 8-K2026-01-13Current report (material event)
- 8-K2025-11-10Current report (material event)
- 10-Q2025-10-31Quarterly report
- 8-K2025-10-29Current report (material event)
- S-82025-08-20Employee stock plan
- SCHEDULE 13G2025-08-12SCHEDULE 13G
- 8-K2025-08-12Current report (material event)
- SCHEDULE 13G/A2025-08-07SCHEDULE 13G/A
- 10-Q2025-08-04Quarterly report
- 8-K2025-07-30Current report (material event)
- 8-K2025-06-03Current report (material event)
- SD2025-05-30SD
- 8-K2025-05-14Current report (material event)
- 10-Q2025-05-01Quarterly report
- 8-K2025-04-30Current report (material event)
- SCHEDULE 13G/A2025-04-29SCHEDULE 13G/A
- ARS2025-04-15Annual report to holders
- DEFA14A2025-04-15DEFA14A
Source: SEC EDGAR. Forms 3/4/5 and 144 (insider transactions) are intentionally left out.