Pipeline — registered trials by phase
Ezetrol Post-Marketing Study
— · Hyperlipidemia · Completed · est. 2008-05
An Observational Study for the Assessment of Compliance and Persistence to Rebif® Therapy of Patients With Relapsing-remitting Multiple Sclerosis (MS) and Evaluation of Potential Factors Influencing These Parameters
— · Multiple Sclerosis, Relapsing-Remitting · Completed · est. 2012-09
Safety, Tolerability, and Pharmacokinetics of Raltegravir (MK-0518) in Healthy Japanese Male Participants (MK-0518-851)
— · Human Immunodeficiency Virus (HIV) Infection · Completed · est. 2018-10-23
The Safety and Effectiveness of Indinavir Sulfate Plus Efavirenz
— · HIV Infections · Completed
A Clinical Trial of MK-2828 in People With Kidney Disease (MK-2828-006)
— · Chronic Kidney Failure, End-Stage Renal Disease, Renal Impairment · Completed · est. 2026-09-01
A Study in Subjects With Retinal Detachment
— · Retinal Detachment · Completed · est. 2002-06
A Single Dose Study of MK-6194 in Healthy Chinese Participants (MK-6194-014)
— · Healthy · Completed · est. 2024-08-09
Three-Dose Regimen of MRKAd5+6 Trigene (V526) in Healthy Adults (V526-001)(COMPLETED)
— · HIV, HIV Infections · Completed · est. 2006-08
A Study to Assess Regional Cerebral Blood Flow as an Alzheimer's Disease Biomarker Compared to Positron Emission Tomography in Patients With Mild-to-Moderate Alzheimer's Disease and Cognitively Normal Elderly Subjects (Study MK-0000-068)(COMPLETED)
— · Alzheimer's Disease · Completed · est. 2010-10
Treatment of Participants With Advanced and/or Refractory Solid Tumors (MK-5108-001)
— · Cancer, Neoplasms, Tumors · Completed · est. 2011-04-04
A Phase 1 Trial of NY-ESO-1 With GLA-SE in Patients With Unresectable or Metastatic Cancer
— · Melanoma, Ovarian Cancer, Sarcoma · Completed · est. 2016-12
Effects of Suvorexant in Patients With Chronic Obstructive Pulmonary Disease (MK-4305-032)
— · Insomnia · Completed · est. 2012-01-20
A Pharmacokinetics Study of MK-7655A in Pediatric Participants With Gram-negative Infections (MK-7655A-020)
— · Suspected or Documented Gram-negative Bacterial Infection · Completed · est. 2020-07-28
Study of MK-7162 in Combination With Pembrolizumab (MK-3475) in Adult Participants With Advanced Solid Tumors (MK-7162-002)
— · Solid Neoplasms · Completed · est. 2020-10-19
Positron Emission Tomography/Computed Tomography (PET/CT) in Relapsed Ovarian Cancer (MK-0000-143)
— · Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer · Completed · est. 2011-10
Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor JPN)
— · Solid Tumors · Completed · est. 2015-01-07
Safety, Tolerability and Pharmacokinetics Study of MK-7252 in Healthy Adult Participants (MK-7252-001)
— · Pharmacokinetics, Cancer · Completed · est. 2018-12-17
A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027)
— · Severe Renal Impairment, Healthy · Recruiting · est. 2027-02-01
Safety and Tolerability of Odanacatib (0822-059)
— · Osteoporosis · Completed · est. 2010-04-26
Phase 1 Study of Intradermal LV305 in Patients With Locally Advanced, Relapsed or Metastatic Cancer Expressing NY-ESO-1
— · Melanoma - Currently Enrolling, Non-small Cell Lung Cancer - Enrollment Completed, Sarcoma - Enrollment Completed · Completed · est. 2018-11-14
Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects
— · Healthy · Completed · est. 2010-09-22
A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)
— · Hodgkin Lymphoma · Completed · est. 2025-09-03
A Study of RPL554 in Patients With Cystic Fibrosis
— · Cystic Fibrosis · Completed · est. 2017-11-03
Effects of Pleconaril Nasal Spray on Common Cold Symptoms and Asthma Exacerbations Following Rhinovirus Exposure (Study P04295)
— · Asthma, Common Cold, Picornavirus Infection · Completed · est. 2007-04
A Bridging Trial Comparing Sugammadex (Org 25969) at Reappearance of T2 in Japanese and Caucasian Participants. Part A: Japanese Participants (P05956)
— · Anesthesia, General · Completed · est. 2006-09-22
Study of Bomedemstat in Participants With Essential Thrombocythemia (IMG-7289-CTP-201/MK-3543-003)
— · Essential Thrombocythemia · Completed · est. 2023-03-23
Use of Sugammadex Administered at 5 Minutes After Administration of 1.2 mg/kg Esmeron® (19.4.205)(P05942)
— · Anesthesia, General · Completed · est. 2004-07-14
Study of Temozolomide in Previously Untreated Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Participants With Low O6-Methylguanine Methyltransferase (MGMT) Expression (P05052)
— · Leukemia, Acute Myeloid, Myelodysplastic Syndrome · Completed · est. 2011-05-09
A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension
— · Pulmonary Arterial Hypertension · Completed · est. 2021-12-21
Cetuximab in Combination With S-1 and Cisplatin in Gastric Cancer
— · Gastric Cancer · Completed · est. 2012-08
A Phase II Trial of Ridaforolimus and Exemestane, Compared to Ridaforolimus, Dalotuzumab and Exemestane in Participants With Breast Cancer (MK-8669-064)
— · Breast Neoplasms · Completed · est. 2014-02-19
MK2461 Phase I/II Study in Patients With Advanced Solid Tumors (MK-2461-002 AM1)(COMPLETED)
— · Neoplasm · Completed · est. 2008-10
MK-3795 (PT2385) for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma (MK-3795-003)
— · VHL Gene Mutation, VHL, VHL Syndrome · Completed · est. 2023-08-30
Efficacy and Safety Evaluation of Recombinant Human Growth Hormone (r-hGH), Saizen®, on a Population of Children With Hypochondroplasia, Treated at Least 3 Years or Until Near Final Height, When Applicable, in Comparison With a Historic Cohort of Non-treated Children
— · Hypochondroplasia · Completed · est. 2017-01-17
r-hLIF for Improving Embryo Implantation in IVF
— · Infertility Implantation Failure · Completed
Safety, Tolerability, and the Body's Ability to Develop Resistance to an Investigational Vaccine for Shingles (V211-007)
— · Shingles · Completed · est. 2003-02
A Dose-Ranging Study to Compare Doravirine (MK-1439) Plus TRUVADA® Versus Efavirenz Plus TRUVADA® in Human Immunodeficiency Virus (HIV)-1 Infected Participants (MK-1439-007)
— · HIV Infections · Completed · est. 2014-12-03
Study of Aprepitant (MK-0869) for Chemotherapy-Induced Nausea and Vomiting (CINV) in Adolescent Participants (MK-0869-097)
— · Vomiting · Completed · est. 2006-09
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
— · Breast Neoplasms, Triple Negative Breast Neoplasms, HR Low-Positive/HER2-Negative Breast Neoplasms · Recruiting · est. 2033-03-23
Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)
— · Biliary Tract Carcinoma · Completed · est. 2022-12-15
Evaluation of Clinical and Microbial Efficacy and Safety of AzaSite Compared to Vehicle for Bacterial Conjunctivitis (C-01-401-003)
— · Bacterial Conjunctivitis · Completed · est. 2006-01
Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)
— · Anesthesia, General · Completed · est. 2009-04-01
MK-0954E Study in Participants With Hypertension (MK-0954E-357)
— · Hypertension · Completed · est. 2012-04-01
Rotavirus Efficacy and Safety Trial (REST)(V260-006)
— · Rotavirus Infections · Completed · est. 2004-10
Evaluation of the Safety and Tolerability of a Higher Potency Dose of an Investigational Vaccine Among Adults 50 Years of Age and Older (V211-009)
— · Healthy · Completed · est. 2004-06
A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010) (KEYNOTE-010)
— · Head and Neck Squamous Cell Carcinoma · Completed · est. 2023-05-30
Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adult Participants With COVID-19 (MK-4482-002)
— · Coronavirus Disease (COVID-19) · Completed · est. 2022-05-05
Study of Pembrolizumab With or Without Platinum-based Combination Chemotherapy Versus Chemotherapy Alone in Urothelial Carcinoma (MK-3475-361/KEYNOTE-361)
— · Urothelial Carcinoma Associated 1 RNA, Human · Completed · est. 2020-04-29
Consistency Lots Vaccine Study (V260-009)
— · Rotavirus Infections · Completed · est. 2004-08
Efficacy and Safety of Ertugliflozin (MK-8835/PF-04971729) With Sitagliptin in the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Diet and Exercise (MK-8835-017)
— · Type 2 Diabetes Mellitus · Completed · est. 2016-02-23
PegIntron Versus Adefovir in the Treatment of Chronic Hepatitis B (CHB) e Antigen Positive Patients in Taiwan (P04498/MK-4031-278)
— · Hepatitis B, Chronic (CHB) · Completed · est. 2009-02
Lot-to-Lot Consistency of V114 in Healthy Adults (V114-020)
— · Pneumococcal Infections, Pneumonia, Pneumococcal · Completed · est. 2020-04-03
A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)
— · Non-small Cell Lung Cancer · Recruiting · est. 2032-12-15
A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002)
— · Clostridium Difficile Infection · Completed · est. 2015-05-22
Fixed Dose Combination of Bisoprolol and Amlodipine in the Treatment of Hypertension
— · Hypertension · Completed · est. 2015-03
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-073)
— · Major Depressive Disorder · Completed · est. 2003-10-03
Safety, Tolerability, and Immunogenicity of Measles, Mumps, Rubella, and Varicella (MMRV) Vaccine Made With an Alternative Manufacturing Process (AMP)(V221-027)
— · Measles, Mumps, Rubella · Completed · est. 2013-07-02
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)
— · Urinary Bladder Neoplasms · Active Not Recruiting · est. 2027-01-31
ElsparAsparaginase
PrimaxinCilastatin Sodium
Source: ClinicalTrials.gov (trials where Merck is lead sponsor; 58 active or completed) and Drugs@FDA (2 approved products). Registry data can include older or partnered programs; the company's own pipeline page is the official list.
SEC filings — insider trading forms excluded
- 10-Q2026-08-07Quarterly report
- 13F-HR2026-08-0713F-HR
- 8-K2026-08-04Current report (material event)
- 11-K2026-06-2411-K
- 11-K2026-06-2411-K
- 11-K2026-06-2411-K
- SD2026-05-29SD
- 8-K2026-05-28Current report (material event)
- 8-K2026-05-22Current report (material event)
- 424B52026-05-20Prospectus (offering)
- FWP2026-05-19FWP
- 424B52026-05-18Prospectus (offering)
- 13F-HR2026-05-1313F-HR
- SC TO-T/A2026-05-05SC TO-T/A
- 10-Q2026-05-04Quarterly report
- SCHEDULE 13G2026-04-30SCHEDULE 13G
- 8-K2026-04-30Current report (material event)
- SC TO-T/A2026-04-24SC TO-T/A
- ARS2026-04-08Annual report to holders
- DEFA14A2026-04-08DEFA14A
- DEF 14A2026-04-08Proxy statement
- SC TO-T2026-04-07SC TO-T
- SCHEDULE 13G/A2026-03-27SCHEDULE 13G/A
- 10-K2026-02-24Annual report
- 13F-HR2026-02-1713F-HR
- 8-K2026-02-03Current report (material event)
- SC TO-T/A2026-01-07SC TO-T/A
- SC TO-T/A2025-12-19SC TO-T/A
- SC TO-T/A2025-12-17SC TO-T/A
- SC TO-T2025-12-05SC TO-T
- 8-K2025-12-04Current report (material event)
- 424B52025-12-03Prospectus (offering)
- FWP2025-12-02FWP
- 424B52025-12-01Prospectus (offering)
- 13F-HR2025-11-1213F-HR
- 10-Q2025-11-05Quarterly report
- 8-K2025-10-30Current report (material event)
- 8-K2025-09-09Current report (material event)
- 424B52025-09-04Prospectus (offering)
- FWP2025-09-03FWP
Source: SEC EDGAR. Forms 3/4/5 and 144 (insider transactions) are intentionally left out.