Pipeline — registered trials by phase
Study of the Penumbra Coil 400 System to Treat Aneurysm
— · Intracranial Aneurysms, Peripheral Aneurysms · Completed · est. 2017-06
BOLT-DVT: Study of the Indigo® Aspiration System When Used in Patients With Deep Vein Thrombosis
— · Deep Vein Thrombosis, DVT · Active Not Recruiting · est. 2025-11-18
FORWARD: Functional Outcomes in Real-World Treatment And Revascularization of Non-dominant and Distal M2 Occlusions
— · Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion · Recruiting · est. 2028-09
Evaluating the Safety and Efficacy of the Indigo® Aspiration System in Acute Pulmonary Embolism
— · Pulmonary Embolism · Completed · est. 2019-03-10
Investigation of Clot in Ischemic Stroke and Hematoma Evacuation
— · Ischemic Stroke, Intracranial Hematoma · Completed · est. 2022-07-22
Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
— · Pulmonary Embolism · Recruiting · est. 2026-12
Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery
— · Peripheral Arterial Occlusion or Emboli · Completed · est. 2015-09
A Randomized, Concurrent Controlled Trial to Assess the Safety and Effectiveness of the Separator 3D as a Component of the Penumbra System in the Revascularization of Large Vessel Occlusion in Acute Ischemic Stroke
— · Acute Ischemic Stroke From Large Vessel Occlusion · Completed · est. 2017-06
Study of the CAT RX Aspiration Catheter When Used in Patients With Large Occlusive Thrombus in Coronary Arteries
— · Coronary Vessel Occlusion · Completed · est. 2021-01-18
A Study of Survival and Outcome After Stroke
— · Ischemic Stroke · Completed · est. 2016-12-22
European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke
— · Ischemic Stroke · Completed · est. 2017-11
Post Market Surveillance to Evaluate the Efficacy and Safety of the INDIGO Aspiration System in Japan
— · Acute Limb Ischemia, Arterial Occlusion Mesenteric Artery Superior, Acute DVT of Lower Extremity · Completed · est. 2025-07-25
COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device
— · Stroke, Ischemic · Completed · est. 2020-01-17
A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo Aspiration System
— · Lower Extremity Acute Limb Ischemia, LE ALI · Completed · est. 2023-01-02
Imaging Guided Patient Selection for Interventional Revascularization Therapy
— · Acute Ischemic Stroke · Completed · est. 2016-09
Assess the Penumbra System in the Treatment of Acute Stroke
— · Ischemic Stroke · Completed · est. 2016-10
MIND: Artemis in the Removal of Intracerebral Hemorrhage
— · Cerebral Hemorrhage, Brain Hemorrhage, Cerebral Parenchymal Hemorrhage · Completed · est. 2024-02-20
THUNDER: Acute Ischemic Stroke Study With the Penumbra System® Including Thunderbolt™ Aspiration Tubing
— · Acute Ischemic Stroke, Large Vessel Occlusion · Completed · est. 2024-09-23
Study to Collect Real-world Performance and Safety Data on Penumbra System® in Population With Acute Ischemic Stroke (AIS).
— · Acute Ischemic Stroke (AIS) · Recruiting · est. 2028-01
Assessing the WAVE Extra Soft Coil in Intracranial Aneurysms and Comparing Imaging Modalities
— · Aneurysm, Brain · Completed · est. 2023-08-02
Comparison of Two Pulmonary Embolism Treatments
— · Pulmonary Embolism Acute · Completed · est. 2025-06-12
Penumbra Imaging Collaborative Study (PICS)
— · Stroke · Completed · est. 2010-12
A Volumetric Coiling in Aneurysm Registry of the Penumbra Coil 400TM System
— · Intracranial Aneurysms · Completed · est. 2017-10-03
Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil
— · Intracranial Aneurysm · Completed · est. 2019-12-27
The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms
— · Wide-neck, Saccular Intracranial Aneurysms · Completed · est. 2016-12
No registered trials in this stage.
Study to Assess the Safety and Effectiveness of the Penumbra System
— · Stroke · Completed · est. 2007-06
No registered trials in this stage.
No approved products listed under this sponsor in Drugs@FDA (partnered or subsidiary products may be listed elsewhere).
Source: ClinicalTrials.gov (trials where Penumbra is lead sponsor; 28 active or completed) and Drugs@FDA (0 approved products). Registry data can include older or partnered programs; the company's own pipeline page is the official list.
SEC filings — insider trading forms excluded
- SCHEDULE 13G2026-08-13SCHEDULE 13G
- 10-Q2026-07-30Quarterly report
- 8-K2026-07-30Current report (material event)
- 8-K2026-06-22Current report (material event)
- SD2026-05-29SD
- 4252026-05-07425
- 8-K2026-05-07Current report (material event)
- 10-Q2026-05-06Quarterly report
- 8-K2026-05-06Current report (material event)
- SCHEDULE 13G2026-04-30SCHEDULE 13G
- ARS2026-04-29Annual report to holders
- DEFA14A2026-04-29DEFA14A
- DEF 14A2026-04-29Proxy statement
- 4252026-04-23425
- 4252026-04-22425
- 4252026-04-17425
- DEFM14A2026-04-01DEFM14A
- SCHEDULE 13G/A2026-03-27SCHEDULE 13G/A
- 4252026-03-03425
- 10-K2026-02-25Annual report
- 8-K2026-02-25Current report (material event)
- SCHEDULE 13G/A2026-02-06SCHEDULE 13G/A
- SCHEDULE 13G/A2026-02-05SCHEDULE 13G/A
- 4252026-02-04425
- 4252026-01-20425
- 4252026-01-16425
- 4252026-01-15425
- 4252026-01-15425
- 4252026-01-15425
- 4252026-01-15425
- 4252026-01-15425
- 4252026-01-15425
- 8-K2026-01-15Current report (material event)
- 10-Q2025-11-05Quarterly report
- 8-K2025-11-05Current report (material event)
- 8-K2025-08-27Current report (material event)
- 10-Q2025-07-29Quarterly report
- 8-K2025-07-29Current report (material event)
- SD2025-05-30SD
- 8-K2025-05-30Current report (material event)
Source: SEC EDGAR. Forms 3/4/5 and 144 (insider transactions) are intentionally left out.